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CONCLUSIONS This study demonstrates that manipulation of nanoparticle surface chemistry can help NPs selectively access distinct cell types and elimination pathways, which help to clinical potential of non-biodegradable NPs.BACKGROUND The underlying mechanism involved in ovarian cancer stemness and chemoresistance remains largely unknown. Here, we explored whether the regulation of c-Kit and plasma membrane prohibitin (PH affects ovarian cancer stemness and chemotherapy resistance. METHODS Mass spectrum analysis and an in vitro kinase