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The Most Effective ADHD Medication For Adults Most of the medications used to treat ADHD are classified into two categories: stimulants and nonstimulants. Stimulants like methylphenidate (Provigil) and amphetamines work by increasing the activity in areas of the brain that control the behaviour and attention. Non-stimulants like guanfacine Clonidine, atomoxetine, and others, work slower than stimulants, but they aid in improving focus, attention, and impulsivity. appear to decrease
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