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004). No significant differences were observed between TZ and donepezil. No significant differences of adverse events were found. CONCLUSIONS TZ and donepezil could bring symptomatic benefit for mild to moderate VaD. Trial registration The protocol had retrospectively registered at clinical trial.gov, Unique identifier NCT02453932, date of registration May 27, 2015; https//www.clinicaltrials.gov/ct2/sho....w/NCT02453932?term=N Estrogen receptor beta (ERβ) was considered as a tumor-inhibiting factor in estrogen-sensitive m

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