https://www.selleckchem.com/pr....oducts/shin1-rz-2994
By contrast, an unrelated, non-antigenic peptide presented by the same MHC molecule does not form a catch bond, instead manifesting a slip bond associated with rapid TCR-pMHC dissociation. In summary, a weak interaction between a TCR and agonist ligand will be dramatically amplified by a catch bond under physical load generated by cell movement during immune surveillance. These new biophysical concepts, TCR mechanosensor and dynamic catch bond formation, begin to reveal how bioforces tune T cell signaling and should be potentially
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