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Finding the Best ADHD Medication For Adults Stimulants such as methylphenidate or amphetamine, (Vyvanse) are quick to balance brain chemicals. These drugs can lead to a loss of appetite, sleep problems, weight changes and tics in certain people. Atomoxetine, in conjunction with other antidepressants such as bupropion, are nonstimulants that are slow in their treatment of ADHD symptoms. They increase norepinephrine which is a chemical in the brain that assists control impulses