https://www.selleckchem.com/pr....oducts/Beta-Sitoster
Pancreatic ductal adenocarcinoma (PDA) and chronic pancreatitis (CP) are characterized by a dense collagen-rich desmoplastic reaction. Discoidin domain receptor 1 (DDR1) is a receptor tyrosine kinase activated by collagens that can regulate cell proliferation, migration, adhesion, and remodeling of the extracellular matrix (ECM). To address the role of DDR1 in PDA, we crossed DDR1-null (DDR1-/-) mice into the KrasG12D/+; Trp53R172H/+; Ptf1aCre/+(KPC) model of metastatic PDA. We found that DDR1-/-; KPC mice progress to differenti
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