https://www.selleckchem.com/pr....oducts/PD-0332991.ht
In this series, the risk was less influenced by the HypoD, increasing steadily between doses of 15 and 70Gy with no clear-cut dose threshold. Over a median follow-up period of 7.5years, hypopituitarism occurred in more than one third of patients irradiated for a skull base meningioma, and this prevalence was time- and dose-dependent. In this setting, the risk of developing hypopituitarism was mainly determined by the irradiated target volume and by the dose delivered to the pituitary gland. Over a median follow-up period of 7.5 years
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