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Protection from HF in non-diabetics had been confirmed for empagliflozin within the EMPagliflozin outcomE tRial in Patients With chrOnic heaRt Failure With Reduced Ejection Fraction (EMPEROR-Reduced) trial. A meta-analysis of DAPA-HF and EMPEROR-Reduced confirmed reductions in all-cause and CV death and also the combined risk of CV demise or worsening HF, as really like in the composite renal endpoint without distinction T2DM, making them first-line therapy for
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