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In total, 13 studies were included in the meta-analysis. Pain has a significantly greater effect on pre-frontal-cortex and sensory-motor areas than nonpainful stimulation on oxyhemodynamics. The effect of pain on sensory-motor areas was greater than the effect of pain on the prefrontal-cortex. There was an effect of centralized pain in the CPP group on oxyhemodynamics from a noxious stimulus compared to control's response to pain. Pain affects the prefrontal and sensory-motor cortices of the brain and can be measured using fNIRS. Implica
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