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The patient was treated with sintilimab a total of 6 times. After the first treatment, the patient was in stable condition. The second treatment was discontinued due to renal insufficiency. The patient was then treated with renal and liver protection for 1.5 months, followed by 5 rounds of immunotherapy. After the sixth round of immunotherapy, the patient presented with leukopenia. In order to determine the causes of adverse reactions, we analyzed the changes of intestinal flora of patients before and after immunotherapy, and summarized t
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