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ADHD Medication UK For Adults The first medication that's usually prescribed is a stimulant, like methylphenidate (Ritalin). It increases the activity of certain parts of the brain which regulate attention and behavior. Long-acting formulations are also available and are the most popular medication for adults with ADHD. They build up gradually in the bloodstream, and prevent the 'crash' that can occur when short-acting medication wears off. Stimulants