https://www.selleckchem.com/pr....oducts/FK-506-(Tacro
Presynaptic mitochondria not only absorb but also release Ca during high frequency stimulation (HFS) when presynaptic [Ca ] is kept low (500nm) by high cytosolic Ca buffer or strong plasma membrane calcium clearance mechanisms under physiological external [Ca ]. Mitochondrial Ca release (MCR) does not alter the global presynaptic Ca transients. MCR during HFS enhances short-term facilitation and steady state excitatory postsynaptic currents by increasing vesicular release probability. The intra-train MCR may provide resi
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