https://alksignals.com/index.p....hp/conjecture-associ
Right here we reveal, making use of a mix of pathway mining of genetic dependency maps, AlphaFold-guided framework predictions and targeted lipidomics, that the uncharacterized transmembrane protein TMEM164-the hereditary ablation of which was demonstrated to protect cells from ferroptosis-is a cysteine active center enzyme that selectively transfers C204 acyl chains from phosphatidylcholine to lyso-ePLs to create PUFA ePLs. Genetic removal of TMEM164 across a set of ferroptosis-sensit
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