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Medications and Therapy For ADHD Combining therapy and medication can help manage ADHD. The medication treats the brain, while therapy helps people cope and develop skills. Stimulants like methylphenidate or Lisdexamfetamine boost the levels of two chemicals that transmit messages between cells in the brain. This can increase attention, impulse control and motivation. Stimulants can cause negative side effects like an increase in appetite, trouble sleeping
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