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How Does Medication For ADHD Work? The most popular medications doctors prescribe to treat ADHD are effective by increasing levels of the chemicals dopamine, and norepinephrine in the brain. They come in both short-acting and extended-release forms. The effects of medications vary for everyone, so it may take some time to determine the right dosage and medication for you or your child. In addition to medications lifestyle changes can also help improve symptoms. Methylphenida