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To help validate our bioinformatics data, one upregulated circRNA and four downregulated circRNAs were analyzed. The circularity of those circRNAs was demonstrated utilizing RNaseR food digestion and Sanger sequencing. The expression of four stable circRNAs undigested by RNaseR had been further validated by quantitative PCR. In conclusion, this study unearths several circRNAs as book and potentially effective goals involved

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