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2 ± 24.6 to 44.2 ± 19.8 μmol/L (P less then  0.05) in Group 3. The acyl/free carnitine changed from 0.62 to 0.59 in Group 1 (P = 0.287), from 0.76 to 0.66 in Group 2 (P = 0.054) and from 0.57 to 0.60 in Group 3 (P less then  0.05). Of the 145 patients, 126 continued follow-up for the full 18 months. FC remained in the normal range (36-74 μmol/L) within the 95% CI. FC was considered a strong predictor of carnitine deficiency after 6 months (AUC 0.9146, cut-off value 33.8 μmol/L). FC monitoring is essential for appropriate carnitine suppl

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