https://www.selleckchem.com/pr....oducts/chloroquine.h
The already reported low-yielding and non-sustainable Et3N-mediated homocoupling of levoglucosenone (LGO) into the corresponding LGO-Cyrene™ diketone has been revisited and greened-up. Using methanol as both renewable solvent and catalyst and K2CO3 as safe inorganic base, significantly improved the reaction with regards to yield, purification and green aspects. LGO-Cyrene™ was then subjected to a one-pot H2O2-mediated Baeyer-Villiger oxidation/rearrangement, followed by and acidic hydrolysis to produce a novel sterically hindered bi
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