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The Most Effective ADHD Medication For Adults The majority of medications used to treat ADHD are classified into two groups: stimulants and nonstimulants. The stimulants like methylphenidate (Provigil) and amphetamines work by increasing the activity in areas of the brain that regulate attention and behaviour. Non-stimulants, like atomoxetine (Strattera) and guanfacine (Intuniv) and clonidine (Kapvay) perform slower than stimulants but help improve concentration, focus and impulsivity. They also appear to reduce anxiety, which is frequent
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