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OBJECTIVES To identify the level of comfort and religious-spiritual coping of family members of intensive care unit patients and to analyse the sociodemographic/clinical variables that influence this association. METHODS Cross-sectional study on the adult and paediatric intensive care units of two public hospitals in the state of São Paulo, between January and September 2016. Participants were divided into two groups adult (n = 96) and paediatric (n = 7. We used the religious-spiritual coping brief (RSC-Brief) and the comfort scale fo