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02 (95%CI 1.75-2.33) and 2.05 (1.82-2.32) respectively. HF and CKD were separately associated with significantly increased mortality risks and the combination was associated with the highest cardiovascular- and all-cause mortality risk, HR 3.91 (3.02-5.07) and 3.14 (2.90-3.4. CONCLUSION In a large multinational study of 750 000 CVRD-free T2D patients, HF and CKD were consistently the most frequent first CVD manifestations and also associated with increased mortality risks. These novel findings show these cardiorenal diseases to b
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