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Univariate and multivariate evaluation based on clinical traits and TIME-related expression patterns (as examined by IHC) were done to approximate prognosis and had been validated by prognostic nomograms. Both LUAD and lung cancer clients with high CD28 expression had shorter disease-free survival (DFS) (P = 0.0011; P = 0.0001) but longer overall survival (OS) (P = 0.0001; P = 0.0282). TIME-related particles coupled with medical information and genomic signatures could anticipate the prognosis of