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Ding, Yanping, Jianfeng Liu, Yuanqing Xu, Xiaoqing Dong, and Baoping Shao. Evolutionary adaptation of aquaporin-4 in yak (Bos grunniens) brain to high-altitude hypoxia of Qinghai-Tibetan Plateau. High Alt Med Biol 00000-000, 2020. Background In high-altitude animals, brain cell resilience against hypoxia stress is one critical evolutionary step that has promoted individual survival and species adaptation to the environment. Aquaporin-4 (AQP4) is implicated in a number of physiopathological processes, particularly in the dev

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