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Fluoxetine improved the FMMS (P less then 0.00001) and BI(P less then 0.0001) and showed a tendency of improving NIHSS (P = 0.08). In addition, we found that fluoxetine reduced the rate of new-onset depression (P less then 0.0001) and new antidepressants (P less then 0.0001). Conclusion In post-stroke treatment, fluoxetine did not improve participants' mRS and NIHSS but improved FMMS and BI. This difference could result from heterogeneities between the trials different treatment duration, clinical scales sensitivity, patient age, delay