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However, systemic buspirone reduced burst activity in 6-OHDA-lesioned rats (with or without L-DOPA treatment), whereas 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT), a full agonist of 5-HT1A receptors, induced larger inhibitory effects in sham animals. Neither buspirone nor 8-OH-DPAT markedly modified the low frequency oscillatory activity in the SNr or synchronization within the SNr and with the cortex. In addition, local perfusion of buspirone increased GABA and glutamate release in the SNr of naïve and 6-OHDA-lesioned rats but d
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