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Details of all these cases are available in the public domain. In 2 cases a well-characterized exposure-response relationship provided sufficient justification that differences in the shape of the PK profiles were not clinically relevant. In the remaining 3 cases a thorough characterization of the PK profile along with a risk-based approach provided bases for approval.We report an efficient CuPd nanoparticle (NP) catalyst (3 nm CuPd NPs deposited on carbon support) for catalyzing electrochemical allylic alkylation in water/isopropanol (v/v 1/1) and 0.2 M KH
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