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Most Effective ADHD Medication For Adults Most adults find that medication helps them focus, feel calmer and improve their relationships. Medicines can also help with other treatment options like psychotherapy. Stimulants are the most effective drugs for treating ADHD in adults. These include methylphenidate and amphetamine compounds. Adults can take long-acting drugs that are slow-acting but last for 3 to 6 hours, or short-acting medications multiple times per day. Stimulants
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