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How Does ADHD Medication Work? ADHD is treated with stimulants. They aid in regulating the levels of two brain chemical substances (neurotransmitters) which transmit messages between neurons to improve attention and reduce hyperactivity. 20% of people are not sensitive to stimulants like methylphenidate or amphetamine. This could be due to the body chemistry of the person, or other medications that they are taking. What are the symptoms of ADHD? Consult your child's doctor If you suspect that they have ADHD. 'll perform a physical exam, inclu