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Air pollution can be attributed to the reduction in visibility, less agricultural activity, more health issues, and long-term destruction to infrastructure. This paper aimed to examine the validity of association among the Particulate matter (PM2.5) and number of acute upper respiratory infection (ARI) and Asthma (AS) patients using an autoregressive distributed lag (ARDL) approach. This ARDL model study was conducted in Lahore, Pakistan. We used monthly data of ARI and AS patients acquired from Directorate General Health Services Punja