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The pathway analysis of the most significant module identified from the protein-protein interaction network revealed that the complement and coagulation cascades, staphylococcus aureus infection, cytokine-cytokine receptor interaction, chemokine signaling pathway and phagosome were mainly involved. C3, C3ar1, Kng1, Ptafr, and Fgg may be the critical genes in the complement and coagulation cascades pathway, and staphylococcus aureus in the infection pathway. CONCLUSION Exercise may ameliorate the immune response and inflammatory re