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ADHD Medications - Stimulant Or Non Stimulant? Stimulant medications are the first-choice treatment for ADHD and for a lot of people they work well. However, for some people individuals, they can cause adverse effects or do not help. Doctors may prescribe non-stimulant ADHD medication in lieu of or in conjunction with stimulants. These include medications that treat high blood-pressure, such as clonidine or Guanfaci