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Finding the Best Medication For ADHD It may take some time to find an ADHD medication that works for you. It is essential to be honest with your doctor about how ADHD affects you, so that they can prescribe the best medication for you. Stimulants, which are the most commonly used medication for ADHD can trigger negative side effects, such as anxiety and mood changes. Certain sufferers also experience tics while taking stimulants. Methylphenidate Methylphenidate, the most common medication for ADHD,