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ADHD Medication UK For Adults The first medication prescribed is typically a stimulant such as methylphenidate. It enhances the activity of parts of the brain that control behavior and attention. Long-acting formulations are also on the market and are the preferred medication for adults with ADHD. They build up slowly in the bloodstream, thus avoiding the 'crash" that can occur after short-acting medication wears off. Stimulants Stimulants are the most frequently prescribe