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Does ADHD Medication Work? When a person is prescribed ADHD medication, they are concerned about how long the medication will last and if it works. Here are some straightforward solutions. Stimulants work by adjusting levels of brain chemicals which send messages regarding the level of attention and activity. Norepinephrine, dopamine and other brain chemicals are among them. They are often considered to be the first-line treatment option for adults suffering from ADHD. 1. Stimulants St