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In brain, neuroprotective pathways were identified as potential targets regulated by miRNAs. Our data suggests that miRNAs are necessary for modulating the shift in cellular metabolism during hibernation and regulating neuroprotection in the brain. This study is the first of its kind in a hibernating reptile and provides key insight into this ephemeral phenotype.An amendment to this paper has been published and can be accessed via a link at the top of the paper.Since AlGaN offers new opportunities for the development of the solid state ul