https://vu365114modulator.com/....past-due-graft-damag
Methods Therapeutic aftereffect of BRD4 certain inhibitor JQ-1 on severe gouty joint disease was examined in vivo plus in vitro. Pyroptosis was analyzed by Caspase-1/PI double staining and cleavage of gasdermin D (GSDMD). Expression of key facets involved with BRD4/NF-κB/NLRP3/GSDMD signaling pathway had been assessed by western blot, and colocalization of NLRP3 and ASC was detected utilizing immunofluorescence. In inclusion, the part of BRD4 on monosodium uric-acid crystals (MSU)-induced pyroptosis e
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