https://www.selleckchem.com/pr....oducts/exarafenib.ht
A large, primary intermolecular kinetic isotope effect (KIE = 31.9 ± 1. suggests H-atom abstraction (HAA) is the rate-determining step, indicative of H-atom tunneling being operative. The reaction rate has first order dependence in the catalyst and zeroth order in substrate, consistent with the resting state of the catalyst as the corresponding nickel iminyl radical. The presence of the nickel iminyl was determined by multinuclear NMR spectroscopy observed during catalysis. The activation parameters (ΔH‡ = 13.4 ± 0.5 kcal/mol; ΔS‡=
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