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AIM To validate the prognostic role of a panel of genes previously uncovered by our group to be specific targets of miRNAs differentially expressed in lung carcinoids with aggressive pathological features. METHODS Four genes, namely CREBP1, ACVR2B, LHX2 and KFL12, were identified in a previous study by our group using in silico analysis to be regulated by three miRNAs (miR-409-3p, miR-409-5p and miR-431-5p) which were shown to be down-regulated in aggressive lung carcinoids. These genes were analyzed using real-time PCR in a cohort of 1

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