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001). A correlation between SPISE, HOMA-IR and ISI was also reported in normal-weight children. At the 6.5-year follow-up, lower basal SPISE-but not ISI or HOMA-IR-was an independent predictor of IGR development (OR = 3.89(1.65-9.13), p = 0.002; AUROC 0.82(0.72-0.92), p  0.001). In children, low SPISE index is significantly associated with metabolic abnormalities and predicts the development of IGR in life. In children, low SPISE index is significantly associated with metabolic abnormalities and predicts the development of IGR in li

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