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Collagen turnover is modeled, in part, via stress-dependent alterations in collagen half-life, typically taken inside the selection of 10â€"70 times. By comparison, in this work we introduce a biochemomechanical strategy to model the cellular synthesis of procollagen in addition to its transition from an intermediate state of assembled microfibrils to mature cross-linked fibers, with mechano-regulated reduction. The resulting model can simulate temporal changes in geometry, composition, and stress dur

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