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The Most Effective ADHD Medication For Adults The majority of ADHD medications are classified into two categories: stimulants and non-stimulants. stimulants like methylphenidate and amphetamines stimulate brain areas that control attention and behavior. Non-stimulants, like atomoxetine (Strattera) and Guanfacine (Intuniv) and clonidine (Kapvay), work slower than stimulants but can help impr