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HemosIL AcuStar showed high agreement with the other methods in correctly classify patients with ADAMTS13 values below 10% (Kappa=0.89) and even below 5% (Kappa=0.94) with no false negatives and few false positives (5.40%; 95% CI 2.20 to 8.60%). However, it also tended to underestimate ADAMTS13 levels, especially for the high assay range values (40%) (absolute mean bias of 8.40% (95% CI 6.53 to 10.42%)) when compared to other assays. HemosIL AcuStar is highly sensitive to detect ADAMTS13 values below 10% and 5%. A large prospective

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