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ADHD Medication - Ritalin Ritalin, a chemical called methylphenidate, is effective in managing ADHD symptoms in adults. It can make people feel "up," alert, awake, and full of a an euphoria. ADHD medicines work by affecting two brain chemicals, norepinephrine and dopamine. Most ADHD medications are stimulants, such as Ritalin, Concerta, Focalin and Vyvanse. There are also medications that are not stimulants. Methylphenidate Methylphenidate is a central nervous stimulant is the most