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Would it be a problem if these approaches eventually became independent of any specialist clinical diagnostic supervision? If a theranostic technique is shown to work, following its own logic, do we still need an independent 'traditional' diagnosis prior to its use? We argue that such a diagnosis would no longer be necessary provided certain conditions are fulfilled. Orolingual angioedema (OA) after intravenous thrombolysis (IVT) with alteplase in acute stroke can be a life-threatening complication. Our aim was to describe its incide