https://www.selleckchem.com/pr....oducts/lipofermata.h
Following their exit from the thymus, T cells are endowed with potent effector functions but must spare host tissue from harm. The fate of these cells is dictated by a series of checkpoints that regulate the quality and magnitude of T cell-mediated immunity, known as tolerance checkpoints. In this Perspective, we discuss the mediators and networks that control the six main peripheral tolerance checkpoints throughout the life of a T cell quiescence, ignorance, anergy, exhaustion, senescence and death. At the naive T cell stage, two i
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