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Inclusion criteria did not demand a particular cardiac event at baseline, which aggravated the interpretation of the time-specific results. The majority of the participants was of male gender which could cause bias. The present study only vaguely differentiated between ethnical groups which might cause bias regarding nationality-dependent allele distributions. The present study suggests a time-dependent association of the "L L " genotype with depressive symptoms in CHD patients. 5-HTTLPR/rs25531 might be an important marker to detect r
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