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Further research is needed to i) establish the long-term effectiveness of TRE in weight loss and metabolic health, ii) improve the long-term adherence to ADF and investigate its weight loss independent effects in metabolic health, and iii) determine the mechanisms underlying the potential cardiometabolic benefits of intermittent fasting in humans. Intermittent fasting is a promising nutritional approach against obesity and its related metabolic diseases. Further research is needed to i) establish the long-term effectiveness of TRE in wei