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9; 95% CI 5.7-6.2) as compared to non-opioid analgesics (4.2; 95% CI 4.0-4.5) or no pain medication (2.2; 95% CI 1.9-2.5). Controlling for pain intensity, patients using opioids were more likely to report a pain relief (OR = 1.3; 95% CI 1.1-1.8) as compared to those who used non-opioid analgesics. Overall, opioids appear to be effective and used as intended by the prescribing physician. Overall, opioids appear to be effective and used as intended by the prescribing physician.The 3D embryoid body (E differentiation model is a promising