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The actual C-terminal 12 transmembrane percentage of PC1 goes through about three cleavage situations in vivo. The possible lack of proteins from your C-terminal cytoplasmic pursue involving fibrocystin implies any cleavage occasion near their individual TM domain ahead of launching onto the ELVs. Another highlight is facts the C-terminal tail of PC2 is also cleaved within ELVs. Local serum research into the PCC implies that the entire intricate is actually 2 MDa in proportions which N-terminal GPS/GAIN cleaved PC1 as well as PPC cleaved fibrocystin ect
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