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But, the vascular toxicity of SYP-3343 to zebrafish embryos remains not well understood. In our research, we investigated the effects of SYP-3343 on vascular development and its particular potential system of activity. SYP-3343 inhibited zebrafish endothelial cell (zEC) migration, altered nuclear morphology, and triggered irregular vasculogenesis and zEC sprouting angiogenesis, causing angiodysplasia. RNA sequencing showed that SYP-3343 exposure changed the transcriptional le
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